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The previous study using GFP-labeled strains showed that the crawling speed of leptospires was not associated with disease severity 16

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The result in phase 2 clinical trials was 24.2% mean body weight reduction at 48 weeks with the 12mg dose, and the first phase 3 TRIUMPH-4 trial reported an average of 28.7% weight loss at 68 weeks

45, 54 Our findings that normal pancreatic acinar cells have a low level of expression of GLP-1R is similar to those from some reports 60, 61 but differ from others, which report no GLP-1R in normal pancreatic acinar cells by assessing GLP-1R mRNA levels

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